butabarbital will lessen the extent or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib hasn't been researched.Barbiturates ended up 1st discovered to own medical use in 1903, when a research at Bayer confirmed barbit